Journal
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
Volume 49, Issue -, Pages 101-106Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bse.2013.03.001
Keywords
Sponge; Stelletta sp.; Isomalabaricane triterpenes; Cytotoxicity; PTP1B inhibitor
Funding
- National Marine 863 Project [2013AA092902]
- Natural Science Foundation of China [81273430, 21021063, 21162016, 30730108, 20862013]
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A new isomalabaricane triterpene, stellettin N (1), has been isolated together with five known analogues, stellettin H (2), rhabdastrellic acid A (3), stellettin G (4), stellettin D (5), and 22,23-dihydrostellettin D (6), from the Hainan sponge Stelletta sp. The structure of 1 was elucidated on the basis of detailed spectroscopic analysis of its methyl ester (7) and by comparison of NMR data of 7 with those of related known compounds. Compounds 3-8 were evaluated for their inhibitory activity against hPTP1B and the result showed compound 4 had a strong hPTP1B inhibitory activity with IC50 value of 4.1 +/- 0.9 mu M. Compound 4 also exhibited weak cytotoxicity against A549 and HL-60 cells at a concentration of 10 mu M. Furthermore, the chemotaxonomic significance of these compounds was also summarized. (c) 2013 Elsevier Ltd. All rights reserved.
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