4.7 Article

Adaptive mechanisms that preserve cardiac function in mice without myoglobin

Journal

CIRCULATION RESEARCH
Volume 88, Issue 7, Pages 713-720

Publisher

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/hh0701.089753

Keywords

myoglobin; transgenic mice; metabolism; hypoxia; vasculature

Funding

  1. NHLBI NIH HHS [HL06296, HL54794] Funding Source: Medline
  2. NIAMS NIH HHS [AR40849] Funding Source: Medline

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Mice lacking myoglobin survive to adulthood and meet the circulatory demands of exercise and pregnancy without cardiac decompensation. In the present study, we show that many myoglobin-deficient embryos die in utero at midgestation with signs of cardiac failure. Fetal mice that survive to gestational day 12.5, however, suffer no subsequent excess mortality. Survival in the absence of myoglobin is associated with increased vascularity and the induction of genes encoding the hypoxia-inducible transcription factors 1 alpha and 2, stress proteins such as heat shock protein 27, and vascular endothelial growth factor. These adaptations are evident in late fetal life, persist into adulthood, and are sufficient to maintain normal myocardial oxygen consumption during stressed conditions. These data reveal that myoglobin is necessary to support cardiac function during development, but adaptive responses evoked in some animals can fully compensate for the defect in cellular oxygen transport resulting from the loss of myoglobin.

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