Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 282, Issue 4, Pages 1008-1011Publisher
ACADEMIC PRESS INC
DOI: 10.1006/bbrc.2001.4677
Keywords
5-aminoimidazole-4-carboxamideribonucleoside; AICAR; ALMP-activated protein kinase; fiber-type; mouse; rat; skeletal muscle; 2-deoxyglucose transport
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AMP-activated protein kinase (AMPK) may regulate a number of metabolic processes including glucose transport. 5-Aminoimidazole-4-carboxamide-ribonucleoside (AICAR), an AMPK activator, has been used to study the potential role of AMPK in rat skeletal muscle; however, its effects on glucose transport in mouse skeletal muscle are unknown. Incubation with 2 mM AICAR increased S-deoxyglucose transport in EDL muscle from both rats and mice by 86 and 37%, respectively. In contrast, AICAR did not increase S;deoxyglucose transport in rat soleus muscle, However, AICAR induced a large (81%) increase in 2-deoxyglucose transport in soleus muscles obtained from mice. It is proposed that nonspecificity of the stimulation of glucose transport in mouse muscle may be due to a greater percentage of fast-twitch muscle fibers within the muscles. (C) 2001 Academic Press.
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