Journal
GENES & DEVELOPMENT
Volume 15, Issue 8, Pages 933-938Publisher
COLD SPRING HARBOR LAB PRESS
DOI: 10.1101/gad.877001
Keywords
Werner syndrome; RecQ; helicase; mitotic recombination; genetic instability cancer
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Funding
- NCI NIH HHS [P01 CA077852, R29 CA077607, 1 PO1 CA77852, R29 CA77607] Funding Source: Medline
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The chromosome 8p11-12 Werner syndrome (WRN)locus encodes a RecQ helicase protein of unknown function that possesses both 3' --> 5' helicase and 3' --> 5' exonuclease activities. We show that WRN cell lines display a marked reduction in cell proliferation following mitotic recombination, and generate few viable gene conversion-type recombinants. These findings indicate that WRN plays a role in mitotic recombination, and that a loss of WRN function may promote genetic instability and disease via recombination-initiated mitotic arrest, cell death, or gene rearrangement.
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