Journal
PHYSICAL REVIEW LETTERS
Volume 86, Issue 16, Pages 3666-3669Publisher
AMERICAN PHYSICAL SOC
DOI: 10.1103/PhysRevLett.86.3666
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Pairing of DNA fragments with homologous sequences occurs in gene shuffling, DNA repair, and other vital processes. While chemical individuality of base pairs is hidden inside the double helix, x ray and NMR revealed sequence-dependent modulation of the structure of DNA backbone. Here we show that the resulting modulation of the DNA surface charge pattern enables duplexes longer than similar to 50 base pairs to recognize sequence homology electrostatically at a distance of up to several water layers. This may explain the local recognition observed in pairing of homologous chromosomes and the observed length dependence of homologous recombination.
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