Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 193, Issue 8, Pages 981-986Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.193.8.981
Keywords
immunologic memory; immunity; mucosal; paramyxovirus; CD4(+) T lymphocytes
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Funding
- NHLBI NIH HHS [R01 HL63925] Funding Source: Medline
- NIAID NIH HHS [F32 AI10590, R01 AI37597] Funding Source: Medline
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Although CD4(+) T cells have been shown to mediate protective cellular immunity against respiratory virus infections, the underlying mechanisms are poorly understood. For example, although phenotypically distinct populations of memory CD4(+) T cells have been identified in different secondary lymphoid tissues, it is not known which subpopulations mediate protective cellular immunity. In this report, we demonstrate that virus-specific CD4(+) T cells persist in the lung tissues and airways for several months after Sendai virus infection of C57BL/6 mice. A large proportion of these cells possess a highly activated phenotype (CD44(hi), CD62L(lo), CD43(hi), and CD25(hi)) and express immediate effector function as indicated by the production of interferon gamma after a 5-h restimulation in vitro. Furthermore, intratracheal adoptive transfer of lung memory cells into beta (2)m-deficient mice demonstrated that lung-resident virus-specific CD4(+) T cells mediated a substantial degree of protection against secondary virus infection. Taken together, these data demonstrate that activated memory CD4(+) T cells persisting at mucosal sites play a critical role in mediating protective cellular immunity.
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