Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 217, Issue 1-2, Pages 79-86Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0378-5173(01)00590-7
Keywords
phloretin; 6-ketocholestanol; porcine skin; DSC; diffusion
Categories
Ask authors/readers for more resources
In this study the effect of phloretin (PH) and 6-ketocholestanol (KC) on the permeation of progesterone through porcine skin has been examined. Both PH and KC were incorporated into unilamellar L-cl-phosphatidylcholine (PC) liposomes at different concentrations (7.5, 15, 30 and 60 mol%). In diffusion experiments with porcine skin, both substances, to a different degree, enhanced the steady state flux of progesterone. Tt was increased up to 2.4-fold using 15 mol% KC, and 1.4-fold using 30 mol% PH.. The results indicate an interaction of these two compounds with the lipid components of the stratum corneum. In order to visualise the interaction, differential scanning calorimetry (DSC) measurements were performed on porcine skin, which had been impregnated with KC and PH. Both showed a lowering (similar to 5-6 degreesC) in the lipid phase transition temperature that occurs around 75 degreesC in porcine skin. (C) 2001 Elsevier Science B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available