Synthesis of optically active 2-aminotetraline derivatives via enantioselective ruthenium-catalyzed hydrogenation of ene carbamates

The enantioselective hydrogenation of prochiral ene carbamates. directly derived from 2-tetralone. was completed using a catalytic ruthenium system generated From Ru(COD)(methallyl)(2). an optically pure diphosphine and a strong acid containing a non-coordinating counter anion. (C) 2001 Elsevier Science Ltd, All rights reserved.