4.8 Article

Rh(I)-catalyzed coupling cyclization of N-aryl trifluoroacetimidoyl chlorides with alkynes:: One-pot synthesis of fluorinated quinolines

Journal

ORGANIC LETTERS
Volume 3, Issue 8, Pages 1109-1112

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol006936u

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Rh(I) complexes were found to catalyze the coupling cyclization of N-aryltrifluoroacetimidoyl chlorides with alkynes to afford 2-trifluoromethylated quinolines in good yields, Various alkynes were applied to this cyclization coupling with regioselectivity.

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