Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 914, Issue 1-2, Pages 95-103Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0021-9673(01)00522-2
Keywords
amines, heterocyclic aromatic; aminomethylphenylimidazo[4,5-b]pyridine; pyridines; glucuronides
Funding
- NCI NIH HHS [CA55861] Funding Source: Medline
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We developed a solid-phase extraction LC-MS-MS method for the analysis of the four major metabolites of PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pridine) in human urine after a meal of well-done chicken. Ten volunteers each ate either 150 or 200 g of well-done chicken breast containing 9-21 mug of PhIP. Among the individual volunteers there is 8-fold variation in the total amount of metabolites and 20-fold variation in the relative amounts of individual metabolites, showing individual differences in carcinogen metabolism. PhIP metabolites were also detected in urine from a subject consuming chicken in a restaurant meal, demonstrating the method's sensitivity after real-life exposures. Published by Elsevier Science B.V.
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