Journal
CARBOHYDRATE RESEARCH
Volume 331, Issue 4, Pages 347-368Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0008-6215(01)00042-8
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Humans have fewer protein-coding genes than expected for all the inherent complexities of development. Supplementary factors include the post-translational modification of proteins by glycosylation. The latter term plus transglycosylation, glycosyltransferases, and 'to glycosylate' are used in biochemistry as though they always existed. Instead they have a history that can bring new insights in this science area to younger investigators. The present account describes five decades of findings and ideas on enzymic saccharide synthesis leading, finally to a rational theory that will surely continue to serve the biosciences well in the future. (C) 2001 Elsevier Science Ltd. All rights reserved.
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