Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 42, Issue -, Pages 1311-1315Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST20140157
Keywords
astrocyte; ATP; energy metabolism; glycogen; glycogen phosphorylase; signalling
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Funding
- Wellcome Trust [101844]
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Astrocytic glycogen degradation is an important factor in metabolic support of brain function, particularly during increased neuronal firing. In this context, glycogen is commonly thought of as a source for the provision of energy substrates, such as lactate, to neurons. However, the signalling pathways eliciting glycogen degradation inside astrocytes are themselves energy-demanding processes, a fact that has been emphasized in recent studies, demonstrating dependence of these signalling mechanisms on glycogenolytic ATP.
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