Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 42, Issue -, Pages 1647-1652Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST20140278
Keywords
anti-angiogenic therapy; endothelium; gene expression; glioblastoma; tumour; vascular abnormalization
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Funding
- Swedish Cancer Society
- Swedish Childhood Cancer Society
- Swedish Research Council
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Glioblastoma is characterized by microvascular proliferation and a highly abnormal dysfunctional vasculature. The glioblastoma vessels differ significantly from normal brain vessels morphologically, functionally and molecularly. The present review provides a brief overview of the current understanding of the formation, functional abnormalities and specific gene expression of glioblastoma vessels and the consequences of vascular abnormalization for the tumour microenvironment.
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