Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 42, Issue -, Pages 518-522Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST20140017
Keywords
dicarbonyl compound; glycation; glyoxalase system; skin aging
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Funding
- French Ministere de l'Education Nationale de la Recherche et de Technologie (MENRT) (Universite Pierre et Marie Curie)
- LVMH Recherche [CIFRE (convention industrielle de formation par la recherche) [2010/1404]
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Skin aging is the result of intrinsic chronological aging and photoaging, due to UV exposure, that both share important histological modifications and molecular features, including alterations of proteins. One of the main damage is glycation that occurs when reducing sugars react non-enzymatically with proteins. This reaction also happens when the dicarbonyl compounds GO (glyoxal) and MG (methylglyoxal), which are glucose derivatives, react with proteins. These compounds can be detoxified by the glyoxalase system composed of two enzymes, Glo1 (glyoxalase I) and Glo2 (glyoxalase II). The aims of the present mini-review are to briefly summarize our current knowledge of the biological roles of these enzymes in aging and then discuss the relevance of studying the role of glycation and of detoxifying systems in human skin aging.
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