Journal
SCIENCE
Volume 292, Issue 5517, Pages 737-740Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1058766
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- NINDS NIH HHS [NS18366] Funding Source: Medline
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Slit is secreted by cells at the midline of the central nervous system, where it binds to Roundabout (Robo) receptors and functions as a potent repellent. We found that migrating mesodermal cells in vivo respond to Slit as both an attractant and a repellent and that Robe receptors are required for both functions. Mesoderm cells expressing Robe receptors initially migrate away from Slit at the midline. A few hours after migration, these same cells change their behavior and require Robe to extend toward Slit-expressing muscle attachment sites. Thus, Slit functions as a chemoattractant to provide specificity for muscle patterning.
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