Journal
JOURNAL OF BIOLOGICAL RHYTHMS
Volume 30, Issue 6, Pages 563-568Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0748730415598023
Keywords
aging; sex-differences; behavior; mouse; circadian rhythm
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Mice are used widely for research on circadian, molecular and other processes; however, little is known of circadian age- and, particularly, sex-related changes that occur over the entire lifespan of this species. To shed light on this question, the authors used a longitudinal design for the first continuous actogram measurements of general circadian locomotor activity rhythms unperturbed by photocycle or other experimental manipulations over the lifespan in male and female C57BL/6J mice. These weaning-to-death actograms are the most inclusive undertaken to date. Comparisons of circadian parameters (phase angle of entrainment, length of daily activity, bout length/intensity) were made among 4 life stages (adolescence, adult, middle age, and senescence). The present data reveal the progressive and sex-related changes in general locomotor activity pattern that occur throughout the lifespan. From the overall perspective of this study, there appears to be a need for wider age and sex representation in circadian research.
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