Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 42, Issue -, Pages 742-746Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST20140057
Keywords
cancer; GTPase; HRAS; KRAS; NRAS
Categories
Funding
- North West Cancer Research
- Wellcome Trust
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RAS proteins are key signalling hubs that are oncogenically mutated in 30 % of all cancer cases. Three genes encode almost identical isoforms that are ubiquitously expressed, but are not functionally redundant. The network responses associated with each isoform and individual oncogenic mutations remain to be fully characterized. In the present article, we review recent data defining the differences between the RAS isoforms and their most commonly mutated codons and discuss the underlying mechanisms.
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