Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 42, Issue -, Pages 1256-1260Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST20140086
Keywords
mRNA localization; P-body; Socchoromyces cerevisioe; stress granule
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Funding
- Wellcome Trust [099732/Z/12/Z]
- Wellcome Trust [099732/Z/12/Z] Funding Source: Wellcome Trust
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The localization of mRNA forms a key facet of the post-transcriptional control of gene expression and recent evidence suggests that it may be considerably more widespread than previously anticipated. For example, defined mRNA-containing granules can be associated with translational repression or activation. Furthermore, mRNA P-bodies (processing bodies) harbour much of the mRNA decay machinery and stress granules are thought to play a role in mRNA storage. In the present review, we explore the process of mRNA localization in the yeast Saccharomyces cerevisiae, examining connections between organellar mRNA localization and the response to stress. We also review recent data suggesting that even where there is a global relocalization of mRNA, the specificity and kinetics of this process can be regulated.
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