Journal
TETRAHEDRON
Volume 57, Issue 18, Pages 3869-3873Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4020(01)00228-9
Keywords
haloamine; aminohalogenation; catalysis
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Transition metal-ligand complex-catalyzed regio- and stereoselective aminohalogenation of cinnamic esters has been developed using p-TsNCl2 as the nitrogen and chlorine sources. Dichloro-(1,10-phenanthroline)-palladium (II) as the catalyst can be handled very conveniently due to its property of less hygroscopic as compared with other aminohalogenation catalysts. The reaction is suggested to proceed through the mechanism involving N-tosyl N-chloro aziridinium intermediate. Eight examples are presented with modest to good yields (56-82%) and excellent stereoselectivity (> 10:1). (C) 2001 Elsevier Science Ltd. All rights reserved.
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