Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 41, Issue -, Pages 508-512Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST20120238
Keywords
chromatin organization; chromosome capture; polymer physics; self-organization; strings and binders switch model; thermodynamics
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Funding
- Medical Research Council [MC_U120061476] Funding Source: researchfish
- Medical Research Council [MC_U120061476] Funding Source: Medline
- MRC [MC_U120061476] Funding Source: UKRI
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In the cell nucleus, chromosomes have a complex spatial organization, spanning several length scales, which serves vital functional purposes. It is unknown, however, how their three-dimensional architecture is orchestrated. In the present article, we review the application of a model based on classical polymer physics, the strings and binders switch model, to explain the molecular mechanisms of chromatin self-organization. We explore the scenario where chromatin architecture is shaped and regulated by the interactions of chromosomes with diffusing DNA-binding factors via thermodynamics mechanisms and compare it with available experimental data.
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