Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 41, Issue -, Pages 855-860Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST20130047
Keywords
Argonaute protein; gene silencing; GW182 protein; microRNA (miRNA); RNA interference (RNAi)
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Funding
- Deutsche Forschungsgemeinschaft [SFB 960, FOR855]
- European Research Council (ERC grant 'sRNAs')
- Bavarian Genome Research Network (BayGene)
- Bavarian Systems-Biology Network (BioSysNet)
- European Union (grant 'ONCOMIRs')
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Argonaute proteins interact with small RNAs and facilitate small RNA-guided gene-silencing processes. Small RNAs guide Argonaute proteins to distinct target sites on mRNAs where Argonaute proteins interact with members of the GW182 protein family (also known as GW proteins). In subsequent steps, GW182 proteins mediate the downstream steps of gene silencing. The present mini-review summarizes and discusses our current knowledge of the molecular basis of Argonaute-GW182 protein interactions.
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