Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 41, Issue -, Pages 475-490Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST20130014
Keywords
intracellular survival; lysosome; macrophage; pathogen; phagocytosis; phagosome
Categories
Funding
- Medical Research Council
- Wellcome Trust
- Lister Institute of Preventive Medicine
- National Institute for Health Research Surgical Reconstruction and Microbiology Research Centre
- MRC [G0601171, MR/J008176/1] Funding Source: UKRI
- Medical Research Council [G0601171, MR/J008176/1] Funding Source: researchfish
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Phagocytosis and phagosome maturation are crucial processes in biology. Phagocytosis and the subsequent digestion of phagocytosed particles occur across a huge diversity of eukaryotes and can be achieved by many different cells within one organism. In parallel, diverse groups of pathogens have evolved mechanisms to avoid killing by phagocytic cells. The present review discusses a key innate immune cell, the macrophage, and highlights the myriad mechanisms microbes have established to escape phagocytic killing.
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