Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 41, Issue -, Pages 815-820Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST20130044
Keywords
microRNA (miRNA); microRNA biogenesis; nervous system; neuropathogenesis; synaptic plasticity
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Funding
- Medical Research Council [G1000564]
- Medical Research Council [G1000564] Funding Source: researchfish
- MRC [G1000564] Funding Source: UKRI
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The human nervous system expresses approximately 70% of all miRNAs (microRNAs). Changing levels of certain ubiquitous and brain-specific miRNAs shape the development and function of the nervous system. It is becoming clear that misexpression of some miRNAs can contribute towards neurodevelopmental disorders. In the present article, we review the current knowledge of the role of miRNAs in development and pathogenesis of the nervous system.
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