Journal
JOURNAL OF BIOLOGICAL PHYSICS
Volume 41, Issue 3, Pages 235-246Publisher
SPRINGER
DOI: 10.1007/s10867-015-9375-2
Keywords
Gene expression; mRNA noise; Semi classical path integral
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Funding
- IISER Pune
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Gene regulatory networks in cells allow transitions between gene expression states under the influence of both intrinsic and extrinsic noise. Here we introduce a new theoretical method to study the dynamics of switching in a two-state gene expression model with positive feedback by explicitly accounting for the transcriptional noise. Within this theoretical framework, we employ a semi-classical path integral technique to calculate the mean switching time starting from either an active or inactive promoter state. Our analytical predictions are in good agreement with Monte Carlo simulations and experimental observations.
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