Journal
JOURNAL OF CLINICAL IMMUNOLOGY
Volume 21, Issue 3, Pages 227-233Publisher
KLUWER ACADEMIC/PLENUM PUBL
DOI: 10.1023/A:1011087132180
Keywords
antibody-dependent cellular cytotoxicity; AIDS; HIV-1; CD4+T cell counts; plasma HIV load
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Using our gp120/41-expressing, NK cell activity-resistant CEM.NKR cell clones as targets in HIV-1-specific antibody-dependent cellular cytotoxicity (ADCC) assays, we demonstrate here that the serum titers of anti-HN-l ADCC antibodies bear a significant (P < 0.05) positive correlation with the peripheral blood CD4+ T cell counts and a negative one with the number of copies of HIV-1 RNA in the plasma of HIV-infected individuals. These findings underscore the importance of these antibodies as a protective immune parameter in these infections.
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