Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 41, Issue -, Pages 601-605Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST20130004
Keywords
difference topology; DNA knot; Mu transpososome; recombinase; tangle; topoisomerase
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Funding
- joint Division of Mathematical Sciences (DMS)-National Institute of General Medical Sciences (NIGMS) Initiative [NSF 0800285]
- National Science Foundation (NSF) CAREER Award [DMS1057284]
- Direct For Mathematical & Physical Scien
- Division Of Mathematical Sciences [0800285, 1057284] Funding Source: National Science Foundation
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Difference topology is an experimental technique that can be used to unveil the topological structure adopted by two or more DNA segments in a stable protein-DNA complex. Difference topology has also been used to detect intermediates in a reaction pathway and to investigate the role of DNA supercoiling. In the present article, we review difference topology as applied to the Mu transpososome. The tools discussed can be applied to any stable nucleoprotein complex.
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