Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 41, Issue -, Pages 277-282Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST20120275
Keywords
exosome; extracellular vesicle; HIV; microvesicle; plasma membrane; retrovirus; secreted vesicle
Categories
Funding
- Johns Hopkins University
- National Institutes of Health [R01 DK45787]
Ask authors/readers for more resources
Proteins bud from cells in small single-membraned vesicles (similar to 50-250 nm) that have the same topology as the cell. Known variously as exosomes and microvesicles (EMVs), these extracellular organelles are enriched for specific proteins, lipids, carbohydrates and nucleic acids. EMV biogenesis plays critical roles in protein quality control and cell polarity, and, once released, EMVs can transmit signals and molecules to neighbouring cells via a non-viral pathway of intercellular vesicle traffic. In the present paper, we discuss the cis-acting targeting signals that target proteins to EMVs and mediate protein budding from the cell.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available