Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 40, Issue -, Pages 79-84Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST20110676
Keywords
cancer; metastasis; p38 mitogen-activated protein kinase (p38 MAPK); tumour cell
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Funding
- Spanish Ministerio de Ciencia e Innovacion [BFU2010-17850]
- Consolider Ingenio [CSD2010-0045]
- European Commission [223151]
- Fundacion BBVA
- ICREA Funding Source: Custom
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Cells from primary tumours need to go through several steps to become fully metastatic. During this process, cancer cells acquire the ability to invade, migrate across the surrounding tissue, enter into the circulation and colonize distant organs. In the present paper, we review recent progress in understanding how the p38 MAPK (mitogen-activated protein kinase) signalling pathway participates in the different steps of metastasis. Experimental evidence suggests that tumour cells need to modulate p38 MAPK activity levels to successfully metastasize.
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