Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 40, Issue -, Pages 1123-1128Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST20120122
Keywords
genetics of Parkinson's disease; leucine-rich repeat kinase 2 (LRRK2); neurodegeneration; Parkinson's disease; treatment; Wnt signalling
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Funding
- Wellcome Trust [WT088145MA, WT095010MA]
- Michael J. Fox Foundation
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PD (Parkinson's disease) is a devastating progressive motor disorder with no available cure. Over the last two decades, an increasing number of genetic defects have been found that cause familial and idiopathic forms of PD. In parallel, the importance of Wnt signalling pathways for the healthy functioning of the adult brain and the dysregulation of these pathways in neurodegenerative disease has become apparent. Cell biological functions disrupted in PD are partially controlled by Wnt signalling pathways and proteins encoded by PARK genes have been shown to modify Wnt signalling. This suggests the prospect of targeting Wnt signalling pathways to modify PD progression.
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