Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 40, Issue -, Pages 257-261Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST20110617
Keywords
kinase; phosphoinositide; PtdIns5P; signalling
Categories
Funding
- Biotechnology and Biological Sciences Research Council
- Royal Society [R00461]
- AG Laventis Foundation
- Diabetes UK
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Of the seven phosphoinositides, PtdIns5P remains the most enigmatic. However, recent research has begun to elucidate its physiological functions. It is now clear that PtdIns5P is found in several distinct subcellular locations, and the identification of a number of PtdIns5P-binding proteins points to its involvement in a variety of key processes, including signal transduction, membrane trafficking and regulation of gene expression. Although the mechanisms that control its turnover are not yet fully understood, the existence of multiple pathways for PtdIns5P regulation is consistent with this emerging versatility.
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