Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 40, Issue -, Pages 251-256Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST20110663
Keywords
angiogenesis; cancer; extracellular-signal-regulated kinase 5 (ERK5); microRNA (miRNA); migration; oncogene
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Funding
- Babraham Institute
- Biotechnology and Biological Sciences Research Council
- Association for International Cancer Research and Cancer Research UK
- Association for International Cancer Research
- Biotechnology and Biological Sciences Research Council [BBS/E/B/0000H242, BB/C509190/1] Funding Source: researchfish
- BBSRC [BBS/E/B/0000H242] Funding Source: UKRI
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The MEK5 [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase 5]/ERK5 pathway is the least well studied MAPK signalling module. It has been proposed to play a role in the pathology of cancer. In the present paper, we review the role of the MEK5/ERK5 pathway using the 'hallmarks of cancer' as a framework and consider how this pathway is deregulated. As well as playing a key role in endothelial cell survival and tubular morphogenesis during tumour neovascularization, ERK5 is also emerging as a regulator of tumour cell invasion and migration. Several oncogenes can stimulate ERK5 activity, and protein levels are increased by a novel amplification at chromosome locus 17p11 and by down-regulation of the microRNAs miR-143 and miR-145. Together, these finding underscore the case for further investigation into understanding the role of ERK5 in cancer.
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