Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 40, Issue -, Pages 464-468Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST20110774
Keywords
endoplasmic reticulum (ER); endosomal sorting complex required for transport machinery (ESCRT machinery); epidermal growth factor receptor (EGFR); intraluminal vesicle (ILV); multivesicular endosome/body (MVB); protein tyrosine phosphatase 1B (PTP1B)
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Funding
- Medical Research Council [G0801878]
- Medical Research Council [G0801878] Funding Source: researchfish
- MRC [G0801878] Funding Source: UKRI
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Activated EGFR (epidermal growth factor receptor) undergoes ESCRT (endosomal sorting complex required for transport)-mediated sorting on to ILVs (intraluminal vesicles) of endosomes before degradation in the lysosome. Sorting of endocytosed EGFR on to ILVs removes the catalytic domain of the EGFR from the cytoplasm, resulting in termination of receptor signalling. EGFR signalling is also subject to down-regulation through receptor dephosphorylation by the ER (endoplasmic reticulum)-localized PTP1B (protein tyrosine phosphatase 1B). PTP1B on the cytoplasmic face of the ER interacts with endocytosed EGFR via direct membrane contacts sites between the ER and endosomes. In the present paper, we review the relationship between ER endosome membrane contact sites and ILV formation, and their potential role in the regulation of EGFR sorting on to ILVs, through PTP1B-mediated dephosphorylation of both EGFR and components of the ESCRT machinery.
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