Journal
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
Volume 12, Issue 3, Pages 273-324Publisher
SOC BRASILEIRA QUIMICA
DOI: 10.1590/S0103-50532001000300002
Keywords
isatin; heterocyclic synthesis; drug synthesis; metal complexes
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Isatins (1H-indole-2,3-dione) are synthetically versatile substrates, where they can be used for the synthesis of a large variety of heterocyclic compounds, such as indoles and quinolines, and as raw material for drug synthesis. Isatins have also been found in mammalian tissue and their function as a modulator of biochemical processes has been the subject of several discussions. The advances in the use of isatins for organic synthesis during the last twenty-five years, as well as a survey of its biological and pharmacological properties are reported in this review and in the accompanying supplementary information.
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