Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 40, Issue -, Pages 875-879Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST20120090
Keywords
biomarker; chronic kidney disease (CKD); exosome; microRNA (miRNA); urine
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Funding
- European Social Fund Knowledge Economy Skills Scholarship [501335]
- Cancer Research Wales
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Kidney biopsy is the gold-standard diagnostic test for intrinsic renal disease, but requires hospital admission and carries a 3% risk of major complications. Current non-invasive prognostic indicators such as urine protein quantification have limited predictive value. Better diagnostic and prognostic tests for chronic kidney disease patients are a major focus for industry and academia, with efforts to date directed largely at urinary proteomic approaches. microRNAs constitute a recently identified class of endogenous short non-coding single-stranded RNA oligonucleotides that regulate gene expression post-transcriptionally. Quantification of urinary microRNAs offers an alternative approach to the identification of chronic kidney disease biomarkers.
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