Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 40, Issue -, Pages 896-901Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST20120074
Keywords
BTG/Tob; Ccr4-Not complex; deadenylase; mRNA processing; mRNA decay; ribonuclease
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Funding
- Biotechnology and Biological Sciences Research Council [BB/E02338X/1] Funding Source: researchfish
- BBSRC [BB/E02338X/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/E02338X/1] Funding Source: Medline
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The Ccr4-Not complex is one of the major deadenylase factors present in eukaryotic cells. This multi-subunit protein complex is composed of at least seven stably associated subunits in mammalian cells including two enzymatic deadenylase subunits: one DEDD (Asp-Glu-Asp-Asp)-type deadenylase (either CNOT7/human Caf1/Caf1a or CNOT8/human Pop2/Caf1b/Calif) and one EEP (endonuclease-exonuclease-phosphatase)-type enzyme (either CNOT6/human Ccr4/Ccr4a or CNOT6L/human Ccr4-like/Ccr4b). Here, the role of the human Ccr4-Not complex in cytoplasmic deadenylation of mRNA is discussed, including the mechanism of its recruitment to mRNA and the role of the BTG/Tob proteins.
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