Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 39, Issue -, Pages 563-567Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0390563
Keywords
CD9; focal adhesion; integrin; migration; talin; tetraspanin
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Funding
- Breast Cancer Now [2007MAYPR22] Funding Source: Medline
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Tetraspanin CD9 is associated with integrin adhesion receptors and it was reported that CD9 regulates integrin-dependent cell migration and invasion. Pro- and anti-migratory effects of CD9 have been linked to adhesion-dependent signalling pathways, including phosphorylation of FAK (focal adhesion kinase) and activation of phosphoinositide 3-kinase, p38 MAPK (mitogen-activated protein kinase) and JNK (c-Jun N-terminal kinase). In the present paper, we describe a novel mechanism whereby CD9 specifically controls localization of talin 1, one of the critical regulators of integrin activation, to focal adhesions: CD9-deficiency leads to impaired localization of talin 1 to focal adhesions and correlates with increased motility of breast cancer cells.
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