Journal
JOURNAL OF NATURAL PRODUCTS
Volume 64, Issue 5, Pages 608-611Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np000428b
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A novel biphenylneolignan, 2,6,2 ' ,6 ' -tetramethoxy-4,4 ' -bis(2,3-epoxy-1-hydroxypropyl)biphenyl (1), and two new glycosides named atratoglaucosides A (2) and B (3), were isolated from the roots of Cynanchum atratum, and their structures were determined on the basis of chemical and spectroscopic evidence. The aglycons of 2 and 3 were identified as glaucogenin C and 7-desoxyneocynapanogenin A, a new disecopregnane. A known compound, glaucogenin C 3-O-beta -D-cymaropyranosyl-(1 --> -4)-alpha -L-diginopyranosyl(1 -->4)-beta -D-thevetopyranoside (4), isolated from the same source, showed a significant cytotoxic effect against 212 cells. This substance also gave a significant inhibitory effect on TNF-alpha (tumor necrosis factor-alpha) formation from the RAW 264.7 mouse macrophage-like cell line stimulated with LPS (lipopolysaccharide) and on the N9 microglial cell line stimulated with LPS/IFN-gamma (interferon-gamma).
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