Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 39, Issue -, Pages 20-24Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0390020
Keywords
archaeon; DNA interaction; DNA sliding clamp; proliferating-cell nuclear antigen (PCNA); proliferating-cell nuclear antigen-interacting protein box (PIP-box); replication factor C (RFC)
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Funding
- National Science Foundation [MCB-0815646]
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1048394] Funding Source: National Science Foundation
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PCNA (proliferating-cell nuclear antigen) is a ring-shaped protein that encircles duplex DNA and plays an essential role in many DNA metabolic processes. The PCNA protein interacts with a large number of cellular factors and modulates their enzymatic activities. In the present paper, we summarize the structures, functions and interactions of the archaeal PCNA proteins.
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