Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 39, Issue -, Pages 1000-1005Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0391000
Keywords
cardiovascular disease (CVD); cholesteryl ester-transfer protein (CETP); neutral lipid; phospholipid; triacylglycerol (TAG)
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CETP (cholesteryl ester-transfer protein) is essential for neutral lipid transfer between HDL (high-density lipoprotein) and LDL (low-density lipoprotein) and plays a critical role in the reverse cholesterol transfer pathway. In clinical trials, CETP inhibitors increase HDL levels and reduce LDL levels, and therefore may be used as a potential treatment for atherosclerosis. In this review, we cover the analysis of CETP structure and provide insights into CETP-mediated lipid transfer based on a collection of structural and biophysical data.
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