Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 39, Issue -, Pages 460-465Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0390460
Keywords
aging; autophagy; metabolism; stress; target of rapamycin (TOR); translation
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Funding
- Wellcome Trust Funding Source: Medline
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Genetic down-regulation of a major nutrient-sensing pathway, TOR (target of rapamycin) signalling, can improve health and extend lifespan in evolutionarily distant organisms such as yeast and mammals. Recently, it has been demonstrated that treatment with a pharmacological inhibitor of the TOR pathway, rapamycin, can replicate those findings and improve aging in a variety of model organisms. The proposed underlying anti-aging mechanisms are down-regulated translation, increased autophagy, altered metabolism and increased stress resistance.
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