Journal
PATHOLOGY
Volume 33, Issue 2, Pages 204-205Publisher
CARFAX PUBLISHING
DOI: 10.1080/00313020125013
Keywords
Neisseria gonorrhoeae; PCR; LCR; evaluation; asymptomatic urinary screening
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A comparison between three nucleic acid amplification methods (COBAS AMPLICOR NG, Abbott LCx NG and inhouse cppB gene PCR) for the detection of Neisseria gonorrhoeae was undertaken using non-consecutive urine specimens collected from a high prevalence asymptomatic population (260 patients) from multiple sites in Queensland, Australia. Sensitivity, specificity, positive predictive value and negative predictive value were as follows: COBAS 97.9, 93.9, 78.0, 99.5%; LCx 95.7, 100, 100, 99.1%; cppB 97.9, 100, 100, 99.5%. The results provide further evidence that false-positive COBAS AMPLICOR NG PCR results are a significant problem in our population, and that the Abbott NG LCx is a suitable alternative for screening asymptomatic populations with a high prevalence of N. gonorrhoeae carriage.
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