Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 38, Issue -, Pages 348-352Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0380348
Keywords
Barrett's metaplasia; bile acid; gastro-oesophageal reflux disease (GORD); oesophagitis
Categories
Funding
- NCI NIH HHS [R01 CA134571-02, R01 CA134571, R01-CA134571] Funding Source: Medline
- NIDDK NIH HHS [R01-DK63621, R01 DK063621, R01 DK063621-09] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA134571] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK063621] Funding Source: NIH RePORTER
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The precise mechanisms whereby gastro-oesophageal reflux disease causes reflux oesophagitis and Barrett's oesophagus are not clear, even though these diseases have been known to be linked for many years. Recent studies indicate a role for the reflux-induced inflammatory response of oesophageal squamous epithelial cells and the immune cells in the pathogenesis of reflux oesophagitis. Although reflux oesophagitis commonly heals with oesophageal squamous cell regeneration, in some individuals the oesophagus heals through the process of metaplasia, a condition termed Barrett's oesophagus. Recent studies indicate that individual differences in the reflux-mediated response of oesophageal squamous epithelial cells in the type of immune response and/or in signalling pathways that regulate cell proliferation or cell phenotype may determine whether the oesophagus heals with the regeneration of squamous cells or through Barrett's metaplasia.
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