Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 38, Issue -, Pages 1368-1373Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0381368
Keywords
ionic liquid; mucin; mucin function; mucin glycan; O-glycosylation; oligosaccharide synthesis
Categories
Funding
- Engineering and Physical Sciences Research Council
- Royal Society
- EPSRC [EP/F027222/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/F027222/1] Funding Source: researchfish
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The present article provides an overview on mucins and their role in biological processes, while aiming to familiarize readers with the current tools available for the synthesis of structurally defined mucin-type glycan probes including the advantages and potential applications of using ionic liquids in the synthesis of this important class of oligosaccharides. Furthermore, we also highlight recent developments in glycoarray technology that can enable high-sensitivity and high-throughput analysis of this important class of protein-carbohydrate interactions.
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