Journal
JOURNAL OF IMMUNOLOGY
Volume 166, Issue 9, Pages 5749-5754Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.166.9.5749
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Funding
- NCI NIH HHS [CA1198, T32CA72320] Funding Source: Medline
- NHLBI NIH HHS [HL56002, HL48675] Funding Source: Medline
- NIDCR NIH HHS [DE11785, DE11390] Funding Source: Medline
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Stromal-derived factor-1 (SDF-1) is a CXC chemokine that is believed to be constitutively expressed by stromal cells of numerous tissues. In this report, we demonstrate that dermal fibroblasts and vessels of noninflamed tissues express SDF-1. Unexpectedly, we found that expression of SDF-1 is regulated by inflammation. Expression of SDF-1 by primary cultures of human gingival fibroblasts is potently inhibited by activated macrophages via secretion of IL-1 alpha and TNF-alpha. Levels of SDF-1 mRNA also decrease in acutely inflamed mouse dermal wounds. We propose that SDF-1 functions as a homeostatic regulator of tissue remodeling, whose expression stabilizes existing dermal architecture.
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