Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 38, Issue -, Pages 947-951Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0380947
Keywords
caeruloplasmin; inflammation; lactoferrin; myeloperoxidase; protein-protein interaction
Categories
Funding
- Russian Foundation for Basic Research [09-04-01059]
Ask authors/readers for more resources
The first detailed report of a specific interaction of CP (caeruloplasmin) with another protein described its complex with IF (lactoferrin) in 2000. Since then, several protein-protein interactions involving CP have been reported, mostly concerning iron-containing proteins. The CP-LF complex was studied thoroughly, and evidence of reciprocal effects of CP and LF was obtained. Another specific interaction investigated in detail occurs between CP and MPO (myeloperoxidase). CP-LF, CP-MPO and CP-LF-MPO complexes were found in sera of patients with inflammation. Modelling in vitro allowed understanding of which structural peculiarities of CP and partners allow the modification of their functions in a complex. The present paper reviews the latest data on complexes of CP with IF and MPO, and advances some suggestions about their role in health and disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available