Journal
ULTRASTRUCTURAL PATHOLOGY
Volume 25, Issue 3, Pages 183-192Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/019131201300343810
Keywords
autoschizis; bladder tumor; cell death; T24 ultrastructure; vitamins
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Scanning and transmission electron microscopy were employed to further characterize the cytotoxic effects of a ascorbic acid/menadione (or vitamin C/vitamin K-3) combination on a human bladder carcinoma T24 cell line. Following l-h treatment T24 cells display membrane and mitochondrial defects as well as excision of cytoplasmic fragments that contain no organelles. These continuous self-excisions reduce the cell size. Concomitant, nuclear changes, chromatin disassembly, nucleolar condensation and fragmentation, and decreased nuclear volume lead to cell death via a process similar to karyorrhexis and karyolysis. Because this cell death is achieved through a progressive loss of cytoplasm due to self-morsellation, the authors named this mode of cell death autoschizis (from the Creek autos, self, and schizein, to split, as defined in Scanning. 1998; 20: 564-575). This morphological characterization of autoschizic cell death confirms and extends the authors previous reports and demonstrates that this cell death is distinct from apoptosis.
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