Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 38, Issue -, Pages 1144-1149Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0381144
Keywords
endogenous short interfering RNA; monoallelic gene expression; natural antisense transcript; non-protein-coding RNA; random imprinting; transcriptional silencing
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Funding
- Dunhill Medical Trust
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NATs (natural antisense transcripts) are important regulators of eukaryotic gene expression. Interference between the expression of protein-coding sense transcripts and the corresponding NAT is well documented. In the present review, we focus on an additional, higher-order role of NATs that is currently emerging. The recent discovery of endogenous siRNAs (short interfering RNAs), as well as NAT-induced transcriptional gene silencing, are key to the proposed novel function of NATs.
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