Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 38, Issue -, Pages 1506-1510Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0381506
Keywords
cis encoded element; mRNA decay; RNA quality control; RNA surveillance; trans factor
Categories
Funding
- National Institutes of Health [R01 GM077243, GM007240]
- American Cancer Society [RSG GMC 111896]
- National Science Foundation [MCB 0946464]
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [0946464] Funding Source: National Science Foundation
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Gene expression can be regulated at multiple levels including transcription RNA processing RNA localization translation and finally RNA turnover RNA degradation may occur at points along the processing pathway or during translation as it undergoes quality control by RNA surveillance systems Alternatively mRNAs may be subject to regulated degradation often mediated by cis encoded determinants in the mRNA sequence that through the recruitment of trans factors determine the fate of the mRNA The aim of the present review is to highlight mechanisms of regulated and quality control RNA degradation in eukaryotic cells with an emphasis on mammals
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