Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 37, Issue -, Pages 1385-1388Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0371385
Keywords
ATP; excitotoxicity; glutamate; ischaemia; mitochondrion; oxidative stress
Categories
Funding
- National Institutes of Health [P01 AG02S901, R01 NS4-1908, R01 AG2 1440]
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Chronic exposure to glutamate (glutamate excitotoxicity) exacerbates neuronal damage in the aftermath of stroke and is implicated in a variety of neurodegenerative disorders. mitochondria play a central role in the survival or death of the exposed neuron. calcium, oxidative stress and ATP insufficiency play closely interlocked roles that may be investigated with primary neuronal cultures.
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