Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 37, Issue -, Pages 1007-1013Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0371007
Keywords
dynamic instability; kinesin-13; microtubule-associated protein; microtubule dynamics; microtubule assembly and disassembly regulation; tau protein
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Funding
- Scientific Research NWO Vici and Open programme
- Marie Curie Cancer Cafe
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Proper regulation of MT (microtubule) dynamics is essential for various vital processes, including the segregation of chromosomes, directional cell migration and differentiation. MT assembly and disassembly is modulated by a complex network of intracellular factors that co-operate or antagonize each other, are highly regulated in space and time and are thus attuned to the cell cycle and differentiation processes. While we only begin to appreciate how the concerted action of MT stabilizers and destabilizers shapes different MT patterns, a clear picture of how individual factors affect the MT structure is emerging. in this paper, we review the current knowledge about proteins that modulate MT dynamic instability.
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